When creating the selection list for a backup job with the Backup Exec Agent for VMWare Virtual Infrastructure (AVVI) by default only the complete virtual machine (VM) is selectable.
However there is the possibility via the "Include/Exclude" button to exclude an individual vmdk file from a VM selection list.
Symantec strongly advises against excluding individual vmdk files in a GRT (Granular Restore Technology) enabled backup job with the Backup Exec Agent for VMWare Virtual Infrastructure (AVVI).
Excluding an individual vmdk will have a negative impact on the complete GRT functionality.
If a vmdk file is excluded then Symantec can only support a redirect restore of the remaining vmdk's to the file system. These vmdk's then need to be imported later via a 3rd party tool.
If it is still required not to backup all vmdk's of a VM then Symantec recommends to backup this particular VM like a remote server via the Backup Exec Remote Agent running inside the VM.